Short answer: Amino acid effects on vascular function are cumulative, not acute — skipping days resets the clock, a direct, specific mechanism-based warning.
Why "acute" and "cumulative" are two genuinely different effect types
An acute effect would be immediate and short-lived; a cumulative effect builds gradually with consistency — this direct distinction sets realistic expectations from the outset.
Why this framing directly explains the "skipping days resets the clock" warning
If the effect is genuinely cumulative, missing days doesn't just pause progress — it can meaningfully undo the gradual buildup this mechanism depends on.
💡 Worth knowing: be consistent, same time daily is listed as the second of six specific steps for this exact reason.